Abstract. The Mediterranean region and the Levant have returned some of the clearest evidence of a climatically dry period occurring around 4200 years ago. However, some regional evidence are controversial and contradictory, and issues remain regarding timing, progression and regional articulation of this event. In this paper we review the evidence from selected proxies (sea-surface temperature, precipitation and temperature reconstructed from pollen, δ¹⁸O on speleothems, and δ¹⁸O on lacustrine carbonate) over the Mediterranean basin to infer possible regional climate patterns during the interval between 4.3 and 3.8 cal ka BP. The values and limitations of these proxies are discussed, and their potential for furnishing information on seasonality is also explored. Despite the chronological uncertainties, which are the main limitations for disentangling details of the climatic conditions, the data suggests that winter over the Mediterranean was drier condition, in addition to already dry summers. However, some exceptions to this prevail, – where wetter condition seems to have persisted – suggesting regional heterogeneity in climate patterns. Temperature data, even if sparse, also suggest a cooling anomaly, even if this is not uniform. The most common paradigm to interpret the precipitation regime in the Mediterranean – a North Atlantic Oscillation-like pattern – is not completely satisfactory to interpret the selected data.