We expand here the description of the Antarctic temperature variability during the long interglacial period occurring ~400 thousand years before present (Marine Isotopic Stage, MIS 11). This is achieved thanks to new detailed deuterium measurements conducted on the EPICA Dome C ice core, Antarctica, with a ~50 year temporal resolution. Despite an ice diffusion length reaching ~8 cm at MIS 11 depth, the data allow to highlight a variability at multi-centennial scale for MIS 11, as it has already been observed for the Holocene (MIS 1). Differences between MIS 1 and MIS 11 are analysed regarding the links between multi-millennial trends and sub-millennial variability. The EPICA Dome C deuterium record shows an increased variability and a shift in the observed periodicities at the onset of the final cooling phase of MIS 11, with stronger millennial to multi-millennial variability. Our findings are robust with respect to sensitivity tests on the somewhat uncertain MIS 11 duration.